Allantoin attenuates deficits of behavioural and motor nerve conduction in an animal model of cisplatin‐induced neurotoxicity in rats
First published: 01 July 2019
The aim of the present study was to evaluate the neuroprotective effect of allantoin in cisplatin‐induced toxicity in rats.
Adult male Wistar rats weighing 160‐200 g were used. Neuropathy was induced by injecting cisplatin (2 mg/kg, ip, twice a week for 6 weeks) and the rats were concurrently treated with allantoin (200 and 400 mg/kg, po) for 8 weeks. At the end of the study, body weight and hemogram were measured. Behavioural tests were performed, including tests for cold and hot hyperalgesia, motor co‐ordination, locomotor activity, mechano‐tactile allodynia and mechanical hyperalgesia. The rats were then sacrificed and sciatic nerve conduction velocity was determined. The antioxidant enzyme and nitric oxide levels in sciatic nerve homogenates were measured.
In this study, allantoin restored the motor nerve conduction velocity deficits induced by cisplatin, and the allantoin‐treated rats showed improvement in cold and thermal hyperalgesia, mechano‐tactile allodynia, and mechanical hyperalgesia. Allantoin treatment also improved the rats’ hematological status, increasing haemoglobin, platelet and RBC counts compared to the cisplatin‐treated group. Allantoin treatment also mitigated the functional abnormalities seen in the cisplatin neuropathy group, protecting neurons from the neurotoxic effects of cisplatin.
Allantoin shows promise for use as an adjuvant drug in cancer treatment to protect against cisplatin‐induced neuropathy.
I want to note first and foremost that if anyone tries taking this as a supplement, they should get synthetic allantoin, NOT natural (from the Comfrey plant). The reason being that the plant that produces it also produces small amounts of toxic pyrrolidizine alkaloids, which slowly poison the liver over time. These toxins can not be produced in the process by which allantoin is synthesized in a lab. I buy mine from a place called "Chemistry Connection" in Conway, AR (I get nothing for mentioning this). I buy it by the pound (about $25 US with shipping), and I have used it to speed the healing of soft tissue infections, cuts, burns, a perforated duodenal ulcer (it's been used for that purpose for over 100 years) and last summer when a dog mauled my hand (it healed nearly perfectly). In addition, along with the use of mid-infrared light (880 nm), I have used it to cure sleep apnea, anosmia (lack of a sense of smell) and ageusia (lack of a sense of taste), and it has had a dramatic positive impact on symptoms of my autism and PTSD (almost completely gone). I've also given it to others, from a friend with psoriasis (it helped greatly) to a dog who had knee surgery (he healed quickly).
I've been taking 2.25 grams per day for over a year now, with few breaks (I'm a 220 pound male, 6'1" tall, 52 years old). I feel great, and people have commented (especially women who haven't seen me for a while) on how healthy I look. Despite my being a heavy smoker (working on quitting) and drinking a few times a month, and an unhealthy diet. It is extremely non-toxic. I think if everyone took this, along with Folic Acid (vitamin B9), they would have much fewer health problems, and would age more slowly as well. The only caution I can think of is that I wouldn't put allantoin in my eyes.
Allantoin eats scar tissue, and makes new healthy tissue grow in it's place. It makes all kinds of new cells grow - skin, organ, muscle, mucus membranes and nerve cells. Folic Acid is a necessity (I take 1000 mcg, or 1 milligram, daily - Nutricost brand from Ebay - 240 capsules for $12, free shipping) because there is no new cell growth without it. I have to say that allantoin seems to be as close to a panacea or a cure-all as there is. The Comfrey plant, when taken as a tea, is known as "Knitbone" because it makes broken bones heal rapidly (but see my warning as to the toxins made by this plant. Use synthetic allantoin instead) See below links.
Is Anti-Hypertensive, Markedly Increases Peripheral Blood Flow
Mechanisms of Action in Wound Healing
Grows Brain Cells and Improves Cognitive Function
Toxicity Study (No Appreciable Toxicity)
Regenerates Pancreatic Tissue After Damage
For Treatment of Neurodegenerative Disease and Neurotrauma (Patent)
Allantoin Increased in Serum of Pregnant Women
Allantoin Heals Gastric Ulcers, Known to Saxons The plant's healing abilities were apparently known to the Saxons.
Has Pain-Relieving and Anti-Inflammatory Properties