THE IMPLICATIONS OF SYNTHETIC LIFE
By Jim Taylor
No sooner had I completed last Sunday's column, on attempts to extend life 
by deep-freezing near-death cells, when Craig Venter announced that he had 
created the first synthetic cells. From the end of life, to the origins of 
life. Venter, of course, is the man whose laboratory won the race to 
decipher the human genetic code in June 2000. Now Venter has won another 
race. He claims to have created synthetic life. Well, almost. He didn't 
quite throw together a witches' brew of chemicals from which life 
spontaneously emerged. Rather, he started with something that already had 
life -- a Mycoplasma capricolum bacteria cell -- stripped out its DNA, and 
replaced its DNA with new DNA that he and his colleagues had designed in 
their computers. The donor cell -- or what was left of it -- recognized this 
new stuff as legitimate DNA, and started replicating, just as it would have 
before it lost its own DNA.
A LANDMARK IN BIOLOGY DNA, short for deoxyribonucleic acid, is the blueprint 
for life. Its unique double-helix of paired chemical bonds governs every 
cell of every organism that has ever lived. As a rough analogy, DNA is like 
the operating system for my computer. In effect, Venter simply replaced the 
bacteria's Windows operating system with a Linux system. Venter himself 
implied that analogy. "We were ecstatic when the cells 'booted up'..." 
Venter told the Guardian newspaper. "It's a living species now, part of our 
planet's inventory of life." Geneticist Stephen Scherer of Toronto's 
Hospital for Sick Children, hailed Venter's synthetic DNA, as "a landmark in 
biology having a similar impact to when Dolly the cloned sheep was 
introduced to the world." "This is a moment in evolution," gushed the 
Guardian's Ken MacLoed, "as radical an invention as agriculture or 
industry." Venter certainly views his achievement as a great breakthrough. 
It will, he suggested, enable humans to custom-design organisms that will 
consume greenhouse gases, create fuels, manufacture vaccines.... He didn't 
quite suggest they could produce fully marinated T-bone steaks without the 
inconvenience of raising cattle. But as one journalist noted, somewhat 
acidly, "Dr Venter rarely undersells his work: every advance he makes is a 
breakthrough."
OPENING PANDORA'S BOX But as you might expect, others see mainly risks and 
hazards. Julian Savulescu, professor of practical ethics at Oxford 
University, said: "Venter ... is not merely modifying life by genetic 
engineering. He is going towards the role of a god: creating artificial life 
that could never have existed naturally." The bleakest assessment I've seen 
came from Devinder Sharma of India. Venter, he suggested, "is trying to play 
God. In fact, God now has competition. "The day is not far away when we will 
have a parallel form of life, another living race amidst us. "The day is 
also not far away when biological warfare will acquire ... more deadly and 
sinister forms that synthetic life can create." Sharma called for government 
regulation: "We cannot allow science to be left to corporate board rooms." 
So did L'Osservatore Romano, the Vatican's official newspaper. The emerging 
science, it said, "needs to have rules, like anything that touches the heart 
of life." And Margaret Somerville, founding director of Montreal's McGill 
Centre for Medicine, Ethics and Law, described molecular biology as "the 
power to alter 4.8 billion years of evolution.... We desperately need to 
govern what's okay to do with this and what's not okay."
FREE OF ANCESTORS I don't hold out much hope for legislation. Law always 
lags behind reality. During the millennia when change moved at glacial 
speeds, legislation -- even if it took a generation to formulate -- still 
had time to influence the unfolding of a new technology. Not any more. 
Canada's copyright law, for example, became law in 1985 -- when Internet 
communication was still largely undreamed of. Even frequent amendments leave 
it constantly playing catch-up. Legislators cannot write laws for 
technologies that they have not yet imagined. By the time someone like 
Venter devises a new technology, it's already too late to confine it. "This 
is the first self-replicating species that we've had on the planet whose 
parent is a computer," Venter bragged to reporters -- the first organisms 
since life emerged billions of years ago that have no living ancestor. Aside 
from practical implications, I wonder how the creation of synthetic life 
will affect the way we think about ourselves. All religions have a creation 
story. The details differ, but all presume a single, one-time, creation. How 
will religions deal with parallel creations? Western Christianity has, by 
and large, defined human nature as sinful. Augustine of Hippo theorized that 
Adam and Eve's original sin was transmitted genetically to all generations. 
Since sinful beings could not save each other, salvation must come through 
one considered sinless. If synthetic bacteria have no ancestors, are they 
therefore sinless? Craig Venter himself seems to recognize some broader 
implications of his work, "both scientifically and philosophically. It 
certainly changed my views of the definition of life and how life works," he 
said.            
         
        
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