|Publication number||US5676977 A|
|Application number||US 08/658,955|
|Publication date||Oct 14, 1997|
|Filing date||May 31, 1996|
|Priority date||Sep 22, 1994|
|Also published as||EP1024817A1, EP1024817A4, WO1997045133A1|
|Inventors||Marvin S. Antelman|
|Original Assignee||Antelman Technologies Ltd.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (10), Non-Patent Citations (2), Referenced by (20), Classifications (5), Legal Events (8)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a continuation-in-part of patent application Ser. No. 08/310,859 filed Sep. 22, 1994, now abandoned.BACKGROUND OF THE INVENTION
The present invention relates to the employment of molecular crystals as anti-AIDS devices, but more particularly to the molecular crystal semiconductor tetrasilver tetroxide Ag4 O4 which has two monovalent and two trivalent silver ions per molecule, and which through this structural configuration enables intermolecular electron transfer capable of killing viruses and binding them to the resulting silver entity so that a single intravenous injection will completely obliterate acquired immune deficiency syndrome (AIDS) in humans. Furthermore, said devices are capable of killing pathogens and purging the bloodstream of immune suppressing moieties (ISM) whether or not created by the AIDS virus (HIV); so as to restore the immune system.
The present invention is based on concepts previously elucidated in applicant's U.S. Pat. No. 5,336,499 which discloses the destruction and inhibition of bacteria, algae and the AIDS virus in nutrient life supporting systems by using said silver oxide devices. Example 3 of said patent discloses that 18 PPM of said crystal devices could totally suppress the AIDS virus (page 6, line 5). Subsequent to the filing of the aforementioned patent, further testing revealed complete 100% destruction of the AIDS virus in vitro at 20 PPM, and the fact that said devices were harmless when ingested and inhaled, being non-toxic.
Encouraged by these evaluations and successes, applicant obtained permission to evaluate the crystals in vitro against murine acquired immune deficiency syndrome (MAIDS). Only one facility in the State of Israel is licensed for these evaluations, namely, the Kaplan Hospital in Rehovot, Israel, which is affiliated with the Hebrew University-Hadassah Medical School where said evaluations were done.
The initial evaluations entailed experimenting with various silver moieties cited in applicant's aforementioned patent, concentrations, non-reactive buffers and modes of administration. After about 18 months of judicious efforts and initial failures, success was finally achieved in destroying the MAIDS virus in C57BL mice with a single intravenous injection. The results of this test program comprise Example 5 of U.S. Pat. No. 5,336,499. After success with mice, the inventor was able to test the efficacy of said devices on two select etiological groups of terminal AIDS patients in a clinic in Tegucigalpa, Honduras, Central America.
The AIDS patients comprised the etiological subgroups, Candidiasis and Wasting Syndrome. Current indicator diseases for diagnosing AIDS which have been expanded by the CDC, fall into the following five major categories with the approximate percent distribution among AIDS patients:
______________________________________1. P. carinii pneumonia 51%2. Wasting syndrome 19%3. Candidiasis 13%4. Kaposi's sarcoma 11%5. Dementia 6%______________________________________
This invention concerns itself with the treatment and cure of candidiasis and wasting syndrome AIDS patients with Tetrasil*. These two groups account for approximately one third of AIDS cases.
Stedman's Medical Dictionary (Williams & Wilken's 26th Ed., 1995) defines wasting syndrome "as a condition of 10% weight loss in conjunction with diarrhea or fever . . . Associated with AIDS (p. 1744)."OBJECTS OF THE INVENTION
The main object of the invention is to provide for a molecular scale device of a single tetrasilver tetroxide crystalline molecule capable of restoring the immunity of AIDS afflicted humans of the two AIDS etiological subgroups, candidiasis and wasting syndrome.
Another object of the invention is to provide for immunity restoration in said AIDS afflicted humans through a single injection.
Another object of this invention is to destroy ISM in humans manifesting AIDS diseases of said AIDS etiological subgroups irrespective as to whether said ISM was HIV induced, since it is known that humans may manifest AIDS and still be HIV negative, and thus restore the immune system in said humans.
Another object of this invention is to destroy the AIDS virus when present in the systems of said AIDS afflicted humans.SUMMARY OF THE INVENTION
This invention relates to a molecular scale device not only capable of destroying the AIDS virus, but of purging the human bloodstream of pathogens and restoring immunity to AIDS patients of the candidiasis and wasting syndrome categories. Said molecular device consists of a single crystal of tetrasilver tetroxide (Ag4 O4). The crystal lattice of this molecule has a unique structure since it is a diamagnetic semiconducting crystal containing two mono and two trivalent silver ions, which in effect are capable of "firing" electrons under certain conditions which will destroy AIDS viruses, other pathogens and immune suppressing moieties (ISM), not only through the electrocution mode, but also by a binding process which occurs simultaneously with electron firing, namely, binding and chelation of divalent silver, i.e., the resulting product of the electron transfer redox that occur when the monovalent silver ions are oxidized and the trivalent ions are reduced in the crystal. The binding/chelation effect occurs at active sites of the AIDS virus, pathogens and ISM. Because of the extremely minute size of a single molecule of this crystal, several million of these devices may be employed in concert to destroy a virus colony to purge a life support system of ISM and pathogens with the consumption of only parts per trillion of the crystal devices. Thus an optimum of 40 PPM of the devices by weight of human blood was found to be sufficient to completely obliterate AIDS. This concentration is slightly over double of the optimum concentration recommended in applicant's aforementioned U.S. patent for the destruction of the human AIDS virus in vitro. Other details concerning the structure of the crystal and its mechanism against pathogens, the AIDS virus and ISM would analogously hold here, and have already been further elucidated in said patent.
The actual destruction of pathogens, ISM and the AIDS virus is effectuated by injection of a suspension of these devices in distilled or deionized water with a non-reacting electrolyte directly, i.e. intravenously, into the bloodstream. A single injection is all that is required under these conditions. Accordingly, humans injected in this manner, upon being inspected after three weeks or more had elapsed and compared with similar humans that had been given placebos, were completely cured of AIDS. The control group still manifested AIDS. Accordingly, the tetrasilver tetroxide device performed in concert with and in full conformity with the ultimate objects of this invention. Furthermore, three out of four wasting syndrome terminal patients and four out of the five candidiasis terminal patients were still alive in 1995 after a year and a half had elapsed from their initial injection. By that time all the AIDS patients had been released from the clinic and allowed to return home.
Other objects and features of the present invention shall become apparent to those skilled in the art when the present invention is considered in view of the accompanying examples. It should, of course, be recognized that the accompanying examples illustrate preferred embodiments of the present invention and are not intended as a means of defining the limits and scope of the present invention.EXAMPLE 1
Five patients afflicted with AIDS of the candidiasis etiological category were segregated for Tetrasil treatment. The rationale for selecting them was based on facts presented in an article by Peter H. Duesberg and Brian J. Ellison entitled "Is The AIDS Virus A Science Fiction?" (Policy Review, Summer 1990 pp. 40-51). Only the factual presentations of the article were utilized and the hypothesis of the authors was ignored. The facts presented in the article related to the method of selecting AIDS patients based on the five aforementioned etiological subgroups targeted by the CDC, and the evidence presented, that there is AIDS without HIV as well as with it so that an anti-viral agent in most instances will not necessarily restore the immunity system.
Evaluations with Tetrasil were conducted on AIDS patients at Lucha Contra el Sida, Comayaguela, Honduras. The patients two weeks prior to inoculation were removed from their AZT, AIDS therapy. Tetrasil was administered at approximately 40 PPM of blood volume per patient as a suspension in a proprietary buffer solution (pH=6.5), supplied by Holipharm Corporation.
The results of evaluations with candidiasis are tabulated in Table I under its disease category. All patients evaluated were terminal. Some, however, were in moderate (m) condition and others in poor (p) as designated in the Table. The I and F designations refer to initial and final values as shown. WBC indicates white cell blood count. The H column, following CD 8, indicates whether hepatomegaly occurred. This was an unfortunate consequence of the treatment which resulted in enlarged livers in all patients except the second one. Despite hepatomegaly, there was no interference with liver function.
The onset of hepatomegaly was not spontaneous and varied from patient to patient, being in the range of 4-16 days.
It should also be noted that shortly after injection of Tetrasil there were indications of fever (symbolized by T in the Ag4 O4 column), sometimes accompanied by fatigue (F). The body temperature was invariably 38.5° C. (101.3° F.). This was indicative of restoration of the immune response of the body, since normally the body will destroy pathogens when the immune system is functional by raising the temperature. The patient who died; first responded favorably to Diflucan, which previously gave no response. He was cured of his candidiasis, but unfortunately succumbed to his previous body damage. All the other candidiasis syndrome people who previously did not respond to the indicated medications subsequently responded after the Tetrasil treatment. Further evidence of the recovery of the AIDS patients manifested itself 30 days after the initial injection when white blood cell counts were taken. They are shown in Table I under the WBC column, which gives the initial and final WBC. All candidiasis patients showed a dramatic increase in their white blood cell counts, indicative of the restoration of their immunity systems.EXAMPLE 2
The above protocol of Example 1 was repeated with AIDS patients exhibiting wasting syndrome. The results of their treatment are tabulated in Table I under the disease category of said syndrome. It should be noted that two of the four wasting syndrome patients showed improved white blood counts. The female patient, whose condition improved from poor and terminal to be among the living, showed a decrease in the WBC. However, she showed an increase in body temperature which was indicative of immune response. The test results indicate that one cannot rely on a single factor to indicate the demise of AIDS. The usual HIV marker CD 4 initial and final are irrelevant. ISM suppression appears to be more critical than the destruction of HIV. AIDS was suppressed, any permanent damage that had been done to the patients in the course of their succumbing to AIDS was not obviously cured or corrected by said crystal device treatment, rather said injury persisted and the patient was improved with respect to AIDS but still suffered from said permanent injury or impairment previously inflicted.
TABLE I__________________________________________________________________________Response of AIDS Patients to Single 40 PPM Ag4
Inoculation Date WeightDISEASE PATIENT Inoc. WBC CD 4 DEATH Lbs.Group Sex Age Medictn 1994 I F I F CD 8 H 1944 I F Ag4
__________________________________________________________________________Candidiasis M p 28 Diflucan 5/5 1,200 4,200 41 -- 221 + 6/11 82 76 T F m 33 " 5/5 6,000 6,700 554 872 394 - 98 98 T F m 33 Ketaconzl 5/27 2,600 3,850 248 181 951 + 123 123 T M p 62 " 6/2 3,300 3,700 89 237 59 + 105 92 F F m 31 Pentamidn 6/2 2,400 3,050 9 181 65 + 121 118 PainWasting M m 27 5/27 3,600 4,600 39 14 709 + 119 120 TSyndrome M m 28 5/27 2,750 -- 10 -- 60 + 7/19 121 119 T, F F p 43 5/27 3,600 2,700 68 246 248 + 101 98 T, F M m 19 5/10 3,850 5,400 137 36 48 + 103 106 T, F__________________________________________________________________________
As this invention may be embodied in several forms without departing from the spirit or essential characteristics thereof, the present embodiments are therefore illustrative and not restrictive, since the scope of the invention is defined by the appended claims rather than by the description preceding them, and all changes that fall within the metes and bounds of the claims or that form their functional as well as conjointly cooperative equivalents, are therefore intended to be embraced by these claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4415565 *||Mar 24, 1981||Nov 15, 1983||The United States Of America As Represented By The Secretary Of The Army||Silver metachloridine in treatment of infections|
|US4915955 *||Sep 5, 1986||Apr 10, 1990||Sanosil Ag.||Process for preparing a disinfectant|
|US4952411 *||Oct 18, 1988||Aug 28, 1990||Trustees Of Columbia University In The City Of New York||Method of inhibiting the transmission of AIDS virus|
|US5073382 *||May 9, 1991||Dec 17, 1991||N. Jonas & Co., Inc.||Divalent silver alkaline bactericide compositions|
|US5078902 *||May 9, 1991||Jan 7, 1992||N. Jonas & Co., Inc.||Divalent silver halide bactericide|
|US5089275 *||May 9, 1991||Feb 18, 1992||N. Jonas & Co., Inc.||Stabilized divalent silver bactericides|
|US5211855 *||Jan 24, 1992||May 18, 1993||N. Jonas & Co., Inc.||Method of treating water employing tetrasilver tetroxide crystals|
|US5223149 *||May 18, 1992||Jun 29, 1993||N. Jonas & Co., Inc.||Trivalent silver water treatment compositions|
|US5336499 *||Nov 5, 1992||Aug 9, 1994||Antelman Technologies, Ltd.||Molecular crystal device for pharmaceuticals|
|US5571520 *||Aug 4, 1994||Nov 5, 1996||Antelman Technologies Ltd.||Molecular crystal redox device for pharmaceuticals|
|1||"Is The AIDS Virus A Science Fiction?" by Peter H. Duesberg and Bryan J. Ellison, Policy Review, Summer 1990, pp. 40-51.|
|2||*||Is The AIDS Virus A Science Fiction by Peter H. Duesberg and Bryan J. Ellison, Policy Review , Summer 1990, pp. 40 51.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6258385||Apr 18, 2000||Jul 10, 2001||Marantech Holding, Llc||Tetrasilver tetroxide treatment for skin conditions|
|US6436420 *||Jan 5, 2000||Aug 20, 2002||Marantech Holding, Llc||High performance silver (I,III) oxide antimicrobial textile articles|
|US6485755||Oct 20, 2000||Nov 26, 2002||Marantech Holding||Methods of using electron active compounds for managing cancer|
|US6645531||Oct 20, 2000||Nov 11, 2003||Marantech Holding Llc||Multivalent electron active compositions and methods of making and using same|
|US6669966||Oct 20, 2000||Dec 30, 2003||Marantech Holding Llc||Compositions for facilitating skin growth and methods and articles using same|
|US6989157 *||Oct 22, 2002||Jan 24, 2006||Nucryst Pharmaceuticals Corp.||Dry powders of metal-containing compounds|
|US7300673||Apr 23, 2004||Nov 27, 2007||Exciton Technologies Inc.||Deposition products, composite materials and processes for the production thereof|
|US7687076||Nov 2, 2007||Mar 30, 2010||Exciton Technologies Inc.||Deposition products, composite materials and processes for the production thereof|
|US7998504||May 27, 2008||Aug 16, 2011||Exciton Technologies Inc.||Deposition products, composite materials and processes for the production thereof|
|US20030180378 *||Oct 22, 2002||Sep 25, 2003||Gillis Scott H.||Dry powders of metal-containing compounds|
|US20040022868 *||Jul 31, 2003||Feb 5, 2004||Marantech Holding Llc||Compositions using tetrasilver tetroxide and methods for management of skin conditions using same|
|US20040229034 *||Apr 23, 2004||Nov 18, 2004||Exciton Technologies Inc.||Deposition products, composite materials and processes for the production thereof|
|US20040265877 *||Apr 28, 2004||Dec 30, 2004||Marantech Holding, Llc||Methods for detecting presence of cellular constituents|
|US20060105057 *||Dec 27, 2005||May 18, 2006||Marantech Holding, Llc||Compositions using tetrasilver tetroxide and methods for management of skin conditions using same|
|US20080075650 *||Nov 2, 2007||Mar 27, 2008||Exciton Technologies Inc.||Deposition products, composite materials and processes for the production thereof|
|US20080075860 *||Nov 2, 2007||Mar 27, 2008||Exciton Technologies Inc.||Deposition products, composite materials and processes for the production thereof|
|US20080233161 *||May 27, 2008||Sep 25, 2008||Exciton Technologies Inc.||Deposition products, composite materials and processes for the production thereof|
|US20120276205 *||Nov 7, 2010||Nov 1, 2012||Aidance Skincare & Topical Solutions Llc||Silver oxide formulations|
|WO2001049303A1 *||Oct 20, 2000||Jul 12, 2001||Marantech Holding Llc||Multivalent electron active compositions and methods of making and using same|
|WO2003043537A1 *||Nov 19, 2001||May 30, 2003||Antelman Marvin W||Improvements in curing aids with tetrasilver tetroxide molecular crystal devices|
|U.S. Classification||424/618, 514/495|
|May 31, 1996||AS||Assignment||
Owner name: ANTELMAN TECHNOLOGIES LTD., RHODE ISLAND
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ANTELMAN, MARVIN S.;REEL/FRAME:008042/0535
Effective date: 19960531
|Apr 5, 2001||FPAY||Fee payment||
Year of fee payment: 4
|Aug 21, 2001||AS||Assignment|
|Apr 12, 2005||FPAY||Fee payment||
Year of fee payment: 8
|Jun 15, 2005||AS||Assignment||
Owner name: MARANTECH HOLDING, LLC, RHODE ISLAND
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ANTELMAN TECHNOLOGIES, LTD.;REEL/FRAME:016334/0181
Effective date: 20011118
|Apr 20, 2009||REMI||Maintenance fee reminder mailed|
|Oct 14, 2009||LAPS||Lapse for failure to pay maintenance fees|
|Dec 1, 2009||FP||Expired due to failure to pay maintenance fee||
Effective date: 20091014
You need to be a member of 12160 Social Network to add comments!
Join 12160 Social Network