Small Trial Results: Hydroxychloroquine Effective For COVID-19 Treatment

Small Trial Results: Hydroxychloroquine Effective For COVID-19 Treatment


1
404
https://www.veteranstoday.com/wp-content/uploads/COVID-19_001-320x140.jpg 320w, https://www.veteranstoday.com/wp-content/uploads/COVID-19_001-640x2... 640w, https://www.veteranstoday.com/wp-content/uploads/COVID-19_001-768x3... 768w" sizes="(max-width: 1000px) 100vw, 1000px" alt="" title="COVID-19_001" />

HCQ Effective for COVID-19 in Small Randomized Trial

by Molly Walker, Associate Editor, MedPage Today

Hospitalized patients in China with COVID-19 coronavirus treated with hydroxychloroquine (HCQ), an antimalarial also used to treat autoimmune diseases, had a shorter time to clinical recovery, as well as improved pneumonia, a randomized trial found.

Patients randomized to receive hydroxychloroquine with standard treatment had a significantly shorter time to body temperature recovery of about a day, as well as a significantly reduced time to cough remission of about a day versus patients receiving only standard treatment, reported Zhan Zhang, MD, of Wuhan University in China, and colleagues.

Moreover, a larger proportion of patients in the HCQ group had improved pneumonia compared with patients in the control group (80.6% vs 54.8%), they wrote in a manuscript posted on the medRxiv preprint server.

HCQ and chloroquine for COVID-19 treatment have been in the spotlight ever since President Trump first touted their benefits in a press briefing 2 weeks ago. The FDA said it was looking into conducting randomized trials of the drug in COVID-19 patients, though some hospitals have already opted for off-label use of these agents.

One person in Arizona died after ingesting chloroquine phosphate, also sold for cleaning fish tanks, prompting the CDC to issue a warning against this practice.

Previous trials had explored in vivo activity of the drug, and one pilot study found no benefit in clinical measures or viral clearance compared with standard of care.

Still, the drug continues to be tested in ad hoc trials, including this one by Zhang and colleagues. They randomized 62 patients hospitalized with laboratory-confirmed COVID-19 infection in February. All patients received standard treatment, including oxygen therapy, antiviral agents, antibacterial agents, and immunoglobulin, with or without corticosteroids; patients in the intervention group also received oral HCQ sulfate tablets 400 mg/day on days 1-5.

Primary endpoint was time to clinical recovery, defined as “return to body temperature and cough relief, maintained for more than 72 [hours].” Mean patient age was about 45 and almost half were men, with no significant differences in the age and sex distribution between groups, the authors said.

Patients in the HCQ group had a significantly shorter time to body temperature recovery versus controls (2.2 days vs 3.2 days, P=0.0008). Similar results were seen for time to cough remission for the HCQ and control groups (2.0 vs 3.1 days, P=0.0016).

They noted four of 62 patients progressed to severe illness, all in the control group.

Two patients reported mild adverse reactions in the HCQ group, one with a rash and one with a headache.

Retinopathy is a known side effect of long-term therapy with HCQ — often seen in lupus patients who may stay on the drug for years — and patients occasionally experience arrhythmias and, more rarely, gastrointestinal reactions, cramps, and liver dysfunction. Patients should be monitored for these, but “short-term application of HCQ is relatively safe,” Zhang and colleagues wrote.

While acknowledging a need for large-scale clinical trials and other research to clarify the specific treatment mechanism and optimize the treatment plan, the authors concluded that “considering that there is no better option at present, it is a promising practice to apply HCQ to COVID-19 under reasonable management.”

Disclosures

This study was supported by the Epidemiological Study of COVID-19 Pneumonia to Science and Technology, Department of Hubei Province.

Zhang and co-authors disclosed no relevant relationships with industry.

Views: 11

Comment

You need to be a member of 12160 Social Network to add comments!

Join 12160 Social Network

Comment by stormtruther on April 2, 2020 at 6:59am

Scientists, however, warn about raising false hopes and say major studies are needed to prove the drugs are safe and effective against coronavirus

https://au.news.yahoo.com/the-controversial-drug-approved-to-fight-...

lamestream are against it ...everything they say is bullshit....therefore it probably works, deductive reasoning Dr Watson

Comment by stormtruther on April 2, 2020 at 6:52am

#9 Wormwood

Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, including highly drug-resistant strains.

Artemisinins reduce replication rates of a host of different viruses. Artesunate is effective at stopping viral replication in 100mg per day oral doses (R).

https://men-elite.com/2020/03/13/coronavirus-the-truth-about-the-vi...

Drink Absinth and be merry, I just happen to have one in the yard because i like the buzz....two for the price of one

"Destroying the New World Order"

TOP CONTENT THIS WEEK

THANK YOU FOR SUPPORTING THE SITE!

mobile page

12160.info/m

12160 Administrators

 

Latest Activity

tjdavis posted a video

Charlie Kirk: Grief And Outrage From Turning Point USA in Phoenix

We went to Charlie Kirk's Turning Point USA headquarters in Phoenix to talk with people who were there to pay their respects.►Join my community to get exclus...
3 hours ago
Doc Vega posted blog posts
3 hours ago
Burbia commented on Doc Vega's blog post This Memorable Anthem Given by Nick Freitas Hit the Nail on the Head Please Listen!
8 hours ago
Doc Vega posted blog posts
yesterday
Doc Vega commented on Doc Vega's blog post A Few More Rats in Your Skull Concerning Charlie and the Rampaging Left
"cheeki kea, Yes that was released on to book sites 19 hours before the tragic event and also there…"
yesterday
Burbia commented on Sandy's video
yesterday
Sandy posted a video

Charlie Kirk Was Terrified Of Israel

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
yesterday
Sandy posted a photo
yesterday
cheeki kea commented on Doc Vega's blog post A Few More Rats in Your Skull Concerning Charlie and the Rampaging Left
"The internet is fractioned that's for sure but it never sleeps and the big question of the day…"
yesterday
Burbia commented on Doc Vega's blog post A Few More Rats in Your Skull Concerning Charlie and the Rampaging Left
"It seems America has many meanings to many people. The internet has fractioned everybody. I had…"
Thursday
Doc Vega commented on Doc Vega's blog post Plausible Explanation Behind Recent Cryptid Sightings in the Wild!
"Cheeki kea I'm glad that the giant Moa downsized to this turkey looking land walker.!"
Thursday
Burbia commented on Burbia's blog post Charlie Kirk Assaination
"I don't know what difference if any that he was also a member of Council for National Policy.…"
Thursday
Doc Vega commented on Burbia's blog post Charlie Kirk Assaination
"I remember when they found out that the united Council of Churches worldwide had been funding…"
Thursday
Doc Vega posted a blog post

A Few More Rats in Your Skull Concerning Charlie and the Rampaging Left

 Political violence and death has been perpetrated for a long time now in America. The Democrats…See More
Thursday
Burbia posted a blog post

Charlie Kirk Assaination

September 10th 2025 in Utah Turning Point USA CEO has been assassinated. Coincidentally,  answering…See More
Thursday
Doc Vega posted a blog post

Bow to Your New Masters

 Dr. Jerome Corsi reports that the discovery of a new wireless system that can corrupt any…See More
Tuesday
cheeki kea commented on Doc Vega's blog post Plausible Explanation Behind Recent Cryptid Sightings in the Wild!
"Wow I never knew penguins got down sized also over time. I knew of the Moa which is really now a…"
Tuesday
Sandy posted a video

Civalyze meme

meme ad for a fake drug that would do away with black fatiguecivilyze you're not racist your just exhausted
Monday
Burbia posted a blog post

Is the Timing of Alex Jones and Charlie Sheen Connected?

Alex Jones is sperging out.Charlie Sheen is coming out of the closet.Is this why Alex Jones is…See More
Sep 6
Doc Vega posted a blog post

Buying the Last haunted House on the Left (A partial autobiography)

Note to the reader, there are events here that are true and some that are fictional.Chapter IIt was…See More
Sep 5

© 2025   Created by truth.   Powered by

Badges  |  Report an Issue  |  Terms of Service

content and site copyright 12160.info 2007-2019 - all rights reserved. unless otherwise noted