Allantoin Mitigates Behavioral and Motor Nerve Problems in Animals Treated With Chemo

Allantoin attenuates deficits of behavioural and motor nerve conduction in an animal model of cisplatin‐induced neurotoxicity in rats

First published: 01 July 2019

Abstract -

Background

The aim of the present study was to evaluate the neuroprotective effect of allantoin in cisplatin‐induced toxicity in rats.



Methods

Adult male Wistar rats weighing 160‐200 g were used. Neuropathy was induced by injecting cisplatin (2 mg/kg, ip, twice a week for 6 weeks) and the rats were concurrently treated with allantoin (200 and 400 mg/kg, po) for 8 weeks. At the end of the study, body weight and hemogram were measured. Behavioural tests were performed, including tests for cold and hot hyperalgesia, motor co‐ordination, locomotor activity, mechano‐tactile allodynia and mechanical hyperalgesia. The rats were then sacrificed and sciatic nerve conduction velocity was determined. The antioxidant enzyme and nitric oxide levels in sciatic nerve homogenates were measured.



Results

In this study, allantoin restored the motor nerve conduction velocity deficits induced by cisplatin, and the allantoin‐treated rats showed improvement in cold and thermal hyperalgesia, mechano‐tactile allodynia, and mechanical hyperalgesia. Allantoin treatment also improved the rats’ hematological status, increasing haemoglobin, platelet and RBC counts compared to the cisplatin‐treated group. Allantoin treatment also mitigated the functional abnormalities seen in the cisplatin neuropathy group, protecting neurons from the neurotoxic effects of cisplatin.



Conclusion

Allantoin shows promise for use as an adjuvant drug in cancer treatment to protect against cisplatin‐induced neuropathy.

_________________________________________________________________________________

I want to note first and foremost that if anyone tries taking this as a supplement, they should get synthetic allantoin, NOT natural (from the Comfrey plant). The reason being that the plant that produces it also produces small amounts of toxic pyrrolidizine alkaloids, which slowly poison the liver over time. These toxins can not be produced in the process by which allantoin is synthesized in a lab. I buy mine from a place called "Chemistry Connection" in Conway, AR (I get nothing for mentioning this). I buy it by the pound (about $25 US with shipping), and I have used it to speed the healing of soft tissue infections, cuts, burns, a perforated duodenal ulcer (it's been used for that purpose for over 100 years) and last summer when a dog mauled my hand (it healed nearly perfectly). In addition, along with the use of mid-infrared light (880 nm), I have used it to cure sleep apnea, anosmia (lack of a sense of smell) and ageusia (lack of a sense of taste), and it has had a dramatic positive impact on symptoms of my autism and PTSD (almost completely gone). I've also given it to others, from a friend with psoriasis (it helped greatly) to a dog who had knee surgery (he healed quickly).

I've been taking 2.25 grams per day for over a year now, with few breaks (I'm a 220 pound male, 6'1" tall, 52 years old). I feel great, and people have commented (especially women who haven't seen me for a while) on how healthy I look. Despite my being a heavy smoker (working on quitting) and drinking a few times a month, and an unhealthy diet. It is extremely non-toxic. I think if everyone took this, along with Folic Acid (vitamin B9), they would have much fewer health problems, and would age more slowly as well. The only caution I can think of is that I wouldn't put allantoin in my eyes.

Allantoin eats scar tissue, and makes new healthy tissue grow in it's place. It makes all kinds of new cells grow - skin, organ, muscle, mucus membranes and nerve cells. Folic Acid is a necessity (I take 1000 mcg, or 1 milligram, daily - Nutricost brand from Ebay - 240 capsules for $12, free shipping) because there is no new cell growth without it. I have to say that allantoin seems to be as close to a panacea or a cure-all as there is. The Comfrey plant, when taken as a tea, is known as "Knitbone" because it makes broken bones heal rapidly (but see my warning as to the toxins made by this plant. Use synthetic allantoin instead) See below links.

Is Anti-Hypertensive, Markedly Increases Peripheral Blood Flow

Mechanisms of Action in Wound Healing

Grows Brain Cells and Improves Cognitive Function

Toxicity Study (No Appreciable Toxicity)

Regenerates Pancreatic Tissue After Damage

For Treatment of Neurodegenerative Disease and Neurotrauma (Patent)

Allantoin Increased in Serum of Pregnant Women

Allantoin Heals Gastric Ulcers, Known to Saxons  The plant's healing abilities were apparently known to the Saxons.

Has Pain-Relieving and Anti-Inflammatory Properties

Views: 90

Comment

You need to be a member of 12160 Social Network to add comments!

Join 12160 Social Network

Comment by Chris of the family Masters on November 26, 2019 at 1:17am
It's a good idea to save all those health revelations in one file for further use. Big Pharma becomes more irrelevant every day, for me at least.

"Destroying the New World Order"

TOP CONTENT THIS WEEK

THANK YOU FOR SUPPORTING THE SITE!

mobile page

12160.info/m

12160 Administrators

 

Latest Activity

Doc Vega posted blog posts
17 hours ago
Burbia posted a blog post

Former President Trump?

When was this article written? It is attributed to Victor Davis Hanson. He is a Fellow at Hoover…See More
yesterday
Doc Vega posted a blog post

Don’t Go Hunting For Bigfoot

It is October 19, 2019 at 5:46 AM. This will be the last time any visual evidence of Mark is seen…See More
yesterday
tjdavis posted a video

Most Corrupt Series: Elizabeth Warren | Forgotten History

Elizabeth Warren has built her reputation as a "reformer", but her political career has also drawn sharp criticism. Questions have been raised about her fina...
Saturday
Doc Vega commented on Doc Vega's blog post Ashrams and Moonies Perfect Case for Mind Control
"less prone, Thanks for your support Buddy! "
Thursday
Doc Vega posted a photo

main-thumb-ti-6724328-100-cnsgqkrgkrhyeyyerazynmuwoplecnbx

When will they put Trump on Mt. Rushmore?
Thursday
Doc Vega's 4 blog posts were featured
Sep 18
Burbia's blog post was featured

Charlie Kirk Assassination

September 10th 2025 in Utah Turning Point USA CEO has been assassinated. Coincidentally,  answering…See More
Sep 18
Charles Magus's blog post was featured

FURTHER PROOF OF WALK-INS! Prisoners of the Dulce Base by Sherry Shriner

There is a real connection between the Cabal and what is happening at this Undergroung…See More
Sep 18
Less Prone favorited Doc Vega's blog post Ashrams and Moonies Perfect Case for Mind Control
Sep 18
Less Prone commented on tjdavis's blog post Sentient World Simulation
"Cannot open the link"
Sep 18
Tina Sullivan is now a member of 12160 Social Network
Sep 18
Doc Vega posted blog posts
Sep 17
Sandy posted a video

We’re cooked

We’re cooked
Sep 17
Sandy posted a photo
Sep 17
tjdavis posted a video

Tom Horn discusses Masonic view of 2025

Startling perspective by Tom Horn of the upcoming year: 2025
Sep 16
cheeki kea posted a photo
Sep 16
cheeki kea commented on Doc Vega's blog post Grooming the New Generation of Assassins
"It's a distressing state of affairs when evil leftists hardwire impressionable students and…"
Sep 16
Doc Vega commented on Doc Vega's blog post This Memorable Anthem Given by Nick Freitas Hit the Nail on the Head Please Listen!
"Burbia Charlie Kirk's wife is a real firebrand! God bless that poor woman! "
Sep 15
Doc Vega commented on Doc Vega's blog post This Memorable Anthem Given by Nick Freitas Hit the Nail on the Head Please Listen!
"Burbia thanks for the videos! "
Sep 15

© 2025   Created by truth.   Powered by

Badges  |  Report an Issue  |  Terms of Service

content and site copyright 12160.info 2007-2019 - all rights reserved. unless otherwise noted