Mouse Study Suggests ADHD Drug Might Be Addictive

Ritalin, a drug commonly used to treat children with attention-deficit hyperactivity disorder (ADHD), caused changes in the brain cells of mice similar to those seen with cocaine, a new study shows.

The researchers, from The Rockefeller University in New York City, said the findings suggest that chronic exposure to Ritalin in high doses could prove addictive, and highlight the need for more research into its long-term effects.

However, one ADHD expert said he doubted the findings were applicable to children with the condition because the doses used in the study were so high.

Indeed, in experiments with mice, the researchers found that Ritalin in doses higher than those prescribed to treat ADHD caused changes in the reward region of the brain in a way comparable to cocaine. Ritalin and cocaine are both psycho-stimulants, the researchers noted.

"Methylphenidate [Ritalin] and cocaine have similar chemical structures and their pharmacological effects appear to be similar," said study author Yong Kim, a senior research associate at The Rockefeller University.

The findings were published in this week's online issue of the Proceedings of the National Academy of Sciences.

In their experiments, Kim and his colleagues compared the effects of chronic exposure to Ritalin and cocaine in specific reward-related brain regions of mice.

Over two weeks, mice were given daily injections of Ritalin or cocaine. The researchers looked for changes in dendritic spine formation, which is related to the formation of synapses and communication between nerve cells. They also looked for levels of a protein, delta Fos B, which is associated with long-term actions of addictive drugs.

"The results indicate that chronic exposure of methylphenidate, like cocaine, changes neuronal morphology and brain chemistry, but the precise pattern observed is distinct from that of cocaine," Kim said.

The changes in brain chemistry are known to be associated with the process of drug addiction, Kim added.

"Our results show addictive properties of methylphenidate, and imply that chronic exposure of methylphenidate in humans may lead to addiction," he said.

Kim noted that the researchers used higher doses of Ritalin than those prescribed to people. Also, taking the drug orally may not lead to addiction. But, if it's taken in high doses or injected, Ritalin could become addictive, he said.

"Indeed, methylphenidate is widely abused for improving concentration and enhancing performance, or for recreational purposes," Kim said.

But Dr. Jon A. Shaw, director of child and adolescent psychiatry at the University of Miami School of Medicine, thinks there's a greater risk of later substance abuse among children with ADHD who aren't treated with Ritalin.

"There is a lot of evidence that the use of Ritalin decreases the risk of substance abuse and cocaine use in adult life," Shaw said. "Untreated ADHD subjects are at higher risk for substance abuse and misuse of drugs in adulthood than treated ADHD [subjects]," he noted.

Shaw also noted that the mice in the study were given high doses of Ritalin. "Generalizing these findings to adults makes no sense," he said.

Shaw said he has seen only two cases of addiction to Ritalin. In both, the patients were taking higher-than-normal doses and taking them more often than prescribed.

A study published in March 2008 in the American Journal of Psychiatry found that children who are prescribed psycho-stimulants for ADHD are no more likely than their peers to abuse drugs and alcohol as young adults.

Views: 38

Comment

You need to be a member of 12160 Social Network to add comments!

Join 12160 Social Network

"Destroying the New World Order"

THANK YOU FOR SUPPORTING THE SITE!

mobile page

12160.info/m

12160 Administrators

 

TOP CONTENT THIS WEEK

Latest Activity

Larry Flinchpaugh posted blog posts
1 hour ago
Old Denmark posted a video

Massive Fire breaks out at Huawei R&D laboratory in Songshan Lake, Dongguan, China

"A research laboratory of telecommunications equipment maker Huawei Technologies in the city of Dongguan, in southern Guangdong province, caught fire on Frid...
1 hour ago
Central Scrutinizer commented on KLC's group MUSICWARS
3 hours ago
Central Scrutinizer commented on KLC's group MUSICWARS
"Dee Snider's Emotional Stripped Down Version of "We're Not Gonna Take It""
3 hours ago
Larry Flinchpaugh's 2 blog posts were featured
4 hours ago
Less Prone favorited Larry Flinchpaugh's blog post Connection Between the Rockefeller Foundation, Johns Hopkins, and Gates Foundations
4 hours ago
Freedomrox's 2 blog posts were featured
4 hours ago
Less Prone favorited Phyllis Maka's blog post This physical world is the woowoo world We souls create in, spiritual reality is our real world
4 hours ago
Chris of the family Masters's blog post was featured

Gary Barnett: Freedom Starts by Not Wearing a Mask

September 22, 2020"As bad as the ruling and political class's totalitarian response to this…See More
4 hours ago
Aaron's 3 blog posts were featured
4 hours ago
Less Prone favorited Aaron's blog post Judge Scalia’s final wish was to not be smothered with a pillow.
4 hours ago
James Roberts's blog post was featured

Something Big Is Coming

Wow. At least watch the first three minutes. The new Omnibus rime Bill in Victoria, Australia is a…See More
4 hours ago
Less Prone left a comment for John Adam Madison
"Welcome aboard. Opinion is free."
7 hours ago
John Adam Madison is now a member of 12160 Social Network
7 hours ago
Freedomrox posted blog posts
10 hours ago
Burbia posted a video

Hacker 4chan Tricks ANARCHIST U-Haul Driver in HACKED Call, Holly Zoller Admits She Supplied RIOTERS

Get Soap, Support Veterans: https://herosoapcompany.com/discount/Obvious The HERO Known as 4chan does it again. Holly Zoller, pubic figure and Antifa activis...
10 hours ago
cheeki kea commented on Chris of the family Masters's blog post New Zealand Commie.
"Ha, there she goes again, masterminding multi-violations to the bill of rights. (The right to free…"
11 hours ago
Burbia commented on Aaron's blog post The NFL gets woke and goes broke
11 hours ago
Chris of the family Masters posted a discussion

The end result of ignoring evil

Published: Monday, 14 September 2020 11:17Weaponized medicineushers in totalitarianismThe mask will…See More
11 hours ago
cheeki kea favorited Bob Renner's photo
12 hours ago

© 2020   Created by truth.   Powered by

Badges  |  Report an Issue  |  Terms of Service

content and site copyright 12160.info 2007-2019 - all rights reserved. unless otherwise noted