UMDNJ Researcher Awarded $3 Million NIH Grant to Study Effects of Fluoride

NEWARK - A researcher specializing in pharmacogenetics at UMDNJ-New Jersey Dental School has been awarded a grant for more than $3 million to determine the effects of the mineral fluoride on dental and bone health in children.

Water fluoridation has emerged as one of the top public health achievements in the 20th century, reducing the incidence of dental caries (tooth decay) and its associated suffering. It has saved over $25 billion in dental treatment cost over the past decade alone. But scientists have become increasingly aware that the amount of fluoride needed for good health outcomes can vary. Discovering how to predict the right fluoride dose in advance is the major goal of this new study.

The National Institutes of Health (NIH) awarded the five-year grant of $3,157,976 to Dr. Scott R. Diehl, director of the Center for Pharmacogenomics and Complex Disease Research at the UMDNJ-New Jersey Dental School. The project will evaluate some 3,400 school children ages 11 to 15 years in a region of Ireland where fluoride is added to drinking water. During the study, researchers will attempt to identify genetic and environmental risk factors for dental fluorosis, a condition characterized by permanent discoloration and weakening of tooth enamel. The study will also search for genes that influence risk of dental caries (tooth decay), which water fluoridation aims to prevent.

“Studies of human twins have shown that inherited differences are a major reason why some people have extensive tooth decay while others have no decay at all,” Diehl said. “Up until now, only a handful of places in the human genome have been searched for genes related to tooth decay and no searches at all have been conducted for a genetic effect on fluorosis."

The study will screen samples of saliva for harmful or protective bacteria and test for genetic changes that occur within DNA that cause inherited differences among individuals relative to enamel proteins and other biological pathways that involve fluoride. Diehl noted that his team’s study of fluorosis would be the first to use new techniques that allow investigators to search the entire human genome for inherited variation in fluorosis risk.

The study also will assess whether fluoride urinary excretion rates differ between dental fluorosis cases and controls and whether fluorosis susceptibility genes affect excretion rates, according to Diehl. “This represents a first step towards understanding the biological mechanisms underlying individual differences in fluorosis and caries risk.”

The findings from this study may also help to improve the oral health of Newark residents. Diehl recently began a similar study assessing risk factors for dental caries in area children who were treated at the UMDNJ-New Jersey Dental School. Though much smaller than the Irish project, "This local study will allow us to test whether the findings are unique to Ireland or apply more broadly to most populations around the globe," said Diehl.

To arrange an interview with Dr. Diehl, please contact Jerry Carey, UMDNJ News Service, at 973-972-3000.

The University of Medicine and Dentistry of New Jersey (UMDNJ) is the nation’s largest free-standing public health sciences university with more than 5,600 students attending the state's three medical schools, its only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and its only school of public health on five campuses. Annually, there are more than two million patient visits at UMDNJ facilities and faculty practices at campuses in Newark, New Brunswick/Piscataway, Scotch Plains, Camden and Stratford. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, a statewide mental health and addiction services network.

University of Medicine and Dentistry of New Jersey

Name: Jerry Carey
Phone: 973-972-3000
Email: careyge@umdnj.edu

Views: 48

Comment

You need to be a member of 12160 Social Network to add comments!

Join 12160 Social Network

"Destroying the New World Order"

THANK YOU FOR SUPPORTING THE SITE!

mobile page

12160.info/m

12160 Administrators

 

TOP CONTENT THIS WEEK

Latest Activity

Kim Smith replied to Diana's discussion 'Congress has lost a champion': Twitter reacts to death of Elijah Cummings
"Just another racist troublemaker!"
29 minutes ago
Doc Vega commented on Diana's photo
Thumbnail

Comment On Crowd At Trump Dallas Rally

"Tom Arnold is a drugged up asshole who grinds his teeth and fantasizes about waxing his…"
36 minutes ago
Doc Vega posted a blog post
38 minutes ago
Burbia commented on DallasBC's blog post CANADA'S GREAT TRAITOR
"Pierre?"
51 minutes ago
Burbia commented on Diana's photo
Thumbnail

Comment On Crowd At Trump Dallas Rally

"Wow. Tom Arnold hates JFK. I guess Roseann wasn't his Guenevere."
57 minutes ago
Mrs. Tif Morgan posted discussions
1 hour ago
Burbia commented on Chris of the family Masters's photo
1 hour ago
James Roberts favorited Chris of the family Masters's photo
1 hour ago
Boris commented on Diana's photo
1 hour ago
Diana's photo was featured
1 hour ago
DallasBC's blog post was featured

CANADA'S GREAT TRAITOR

I felt it was time to post this old article about TrudeauWe today are paying a big price for this…See More
1 hour ago
Mrs. Tif Morgan replied to Mrs. Tif Morgan's discussion Halle Synagogue Shooting in Germany While Others Jews Celebrated the Killing
" Yes he did, the network team found his video, downloaded it, here in a few we can show you…"
1 hour ago
James Roberts commented on James T. Kirk's blog post How to Identify and Use Kratom – the Painkilling Plant that Substitutes Opioids
"I use kratom almost every day. A friend of mine orders it in bulk (cheap, $75 a kilo), and has…"
2 hours ago
Nathan A. Bauer's blog post was featured

USAma Bin Laden died in December, 2001 of Marfan Syndrome

Usama Bin Laden died in 2001. He was the victim of a degenerative disease known as Marfan Syndrome.…See More
2 hours ago
James T. Kirk's 2 videos were featured
2 hours ago
James Roberts favorited James T. Kirk's blog post How to Identify and Use Kratom – the Painkilling Plant that Substitutes Opioids
2 hours ago

© 2019   Created by truth.   Powered by

Badges  |  Report an Issue  |  Terms of Service

content and site copyright 12160.info 2007-2019 - all rights reserved. unless otherwise noted